RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Nes
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry; Immunofluorescence etc.
Target
TbetaRI
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Nestin promotes pulmonary fibrosis?via?facilitating recycling of TGF-beta receptor I
Year
2021
Function
"Nestin regulates the vesicular trafficking system by promoting recycling of TbetaRI to the cell membrane through Rab11 and thereby contributes to the progression of pulmonary fibrosis. More importantly, precise targeting of Nestin expression within lung myofibroblasts can alleviate lung fibrogenesis and may represent a potential therapeutic strategy for IPF."